Unable to Add Outlook email signature

1) Check for duplicate Office 365 desktop applications. Delete preinstalled desktop apps.

2) Empty temp folder

3) Uninstall Office 365

4) Modify registry keys using regedit.

Please click on the magnifying glass and search for regedit, launch it, and locate the following key for your version of Office and Windows in the Registry:HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Wow6432Node\CLSID\{0006F03A-0000-0000-C000-000000000046}\LocalServer32
 When selecting the key, in the right pane you’ll see a Key Name called (Default) and LocalServer32. The Data field for both Key Names should point to your location for outlook.exe.
§  The (Default) field is most likely currently in the shorthand (8dot3) notation but you can replace it with the full path as well.
§  The LocalServer32 field may currently look like it is full of gibberish or may be missing completely. In that case you can create it via:
Edit-> New-> Multi-String Value
To verify your path to Outlook.exe, it’s best to browse to the path in Explorer first. Common locations are:
§  Outlook 2007 on a 32-bit version of Windows
C:\Program Files\Microsoft Office\Office12\Outlook.exe
§  Outlook 2010 32-bit on a 64-bit version of Windows
C:\Program Files (x86)\Microsoft Office\Office14\Outlook.exe
§  Outlook 2013/Office 365 Home Premium on a 64-bit version of Windows
C:\Program Files\Microsoft Office 15\root\office15\Outlook.exe
After modifying the key, make sure you restart your computer for changes to take effect.

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